Definitely lots of good ideas in this thread
... don't forget many more are compiled in the "MD Tips & Tricks" and "Next Level" documents in the files section. I find both of these well worth reading again and again from time to time, as I think of new ways to apply the ideas as I learn...
One of my favorite ways to build up a big full changing sound is by sampling just a few tracks with one RAM machine and then resampling the results with another, applying various amounts of echo and reverb to each iteration. Resampling just a short section of the first RAM loop is often enough.
Modify the parameters (start/end times, filter settings, etc.) of each RAM machine, as well as the parameters of the reverb and echo (easier with CTR-GB and -RE machines, IMHO) as you jam. Plock the trigs on each RAM-P track variation, or better yet put the same RAM-P machine on multiple tracks, so that the contents of one RAM-R machine can be used to make overlapping sequences, with various parameter settings. Rinse & repeat.
...At first all this can get obnoxious in a hurry, but with a little planning and time spent finding the sweet spots in your settings the results can be amazing.